The present invention provides modified antigen-binding Fab fragments. Also provided are antigen-binding molecules comprising an antigen-binding Fab fragment and compositions comprising the molecules. [Selection] Figure 1本発明は、修飾抗原結合Fab断片を提供する。抗原結合Fab断片を含む抗原結合分子及びその分子を含む組成物も提供される。【選択図】 図1