Guo-Liang Yu,Jian Ni,Reiner L. Gentz,Patrick J. Dillon
申请号：
US12771910
公开号：
US08105589B2
申请日:
2010.04.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
