Methods and systems for orthopedic treatment and bone disease treatment are disclosed. An example method can comprise creating a level set function, receiving bone marrow biopsy data, determining a plurality of parameters of the level set function based on the bone marrow biopsy data, determining a bone marrow interface, and predicting bone mass, bone volume, cell counts and spatial distributions for one or more of, osteoclasts, osteoblasts, pre-osteoblasts, osteocytes, plasma cells, stromal cells, and tumor cells. The disclosed methods and systems can predict treatment outcome of a bone disease for a specific patient. In an aspect, the disclosed methods and systems can incorporate cellular interactions implicitly and therefore do not need to refer explicitly to any of the biochemistry in the system.
