One heat exchanger module (HEM) and system use the flexible substrate with one or more open channels that wherein a substrate cover is glued, therefore forming closed guides in flexible substrate. Thermoelectric coolers (TEC) are attached to the selectable diffusion copper square on the top of substrate cover of heat. One interface cover is attached at the top of TEC, used in the opposite of TEC a compliant thermally conductive material and be finally in contact with a patient. A kind of liquid passes through the access of closing, quasi- as the hot radical for TEC. Electric current is supplied TEC by a controller to cause relative to the TEC that liquid is cooling or heats. The temperature of one or more temperature sensing device detection interface covers is used as being input to the control of TEC supply electric currents. HEM can be used for a variety of medical uses and heat between heating and cooling, cooling, or circulation.
