БЕНШЕРИФ Меруан (US),БЕНСОН Лайза (US),ДАЛЛ Гари Морис (US),ФЕДОРОВ Николай (US),ГАТТО Грегори Дж. (US),ДЖЕНУС Джон (US),ДЖОРДАН Кристен Г. (US),МЭТЬЮ Джейкоб (US),МАЗУРОВ Анатолий А. (US),МЯО Лань (U
申请号：
RU2012140148/15
公开号：
RU2012140148A
申请日:
2012.09.19
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. (2S, 3R) -N- (2 - ((3-pyridinyl) methyl) -1-azabicyclo [2.2.2] oct-3-yl) benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof, essentially free from (2S, 3S) -N- (2 - ((3-pyridinyl) methyl) -1-azabicyclo [2.2.2] oct-3-yl) benzofuran-2-carboxamide or its pharmaceutically acceptable salt, (2R, 3S ) -N- (2 - ((3-pyridinyl) methyl) -1-azabicyclo [2.2.2] oct-3-yl) benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof or (2R, 3R) -N- ( 2 - ((3-pyridinyl) methyl) -1-azabicyclo [2.2.2] oct-3-yl) benzofuran-2-carboxamide or a pharmaceutically acceptable salt thereof. 2. A method for treating or preventing a central nervous system disorder, inflammation, pain or neovascularization, comprising administering a compound according to Claim 1.3. The method of claim 2, wherein the central nervous system disorder is selected from mild cognitive impairment associated with age-related memory impairment, pre-dementia, early onset of Alzheimer's disease, senile dementia, Alzheimer's type dementia, Alzheimer's disease, dementia with Levi bodies, dementia as a result AIDS-related microinfarction dementia, HIV dementia, multiple cerebral infarcts, parkinsonism, Parkinson's disease, Peak's disease, progressive supranuclear palsy, Huntington’s chorea, ozdney dyskinesia, hyperkinesia, mania, disorders associated with attention deficit hyperactivity disorder, attention deficit, anxiety, depression, dyslexia, schizophrenia, cognitive dysfunction in schizophrenia, depression, obsessive-compulsive disorders or Turetta.4 syndrome. The method of claim 2, wherein the central nervous system disorder is selected from Alzheimer's disease, mania, attention deficit disorder disorder,1. (2S,3R)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамид или его фармацевтически приемлемая соль, по существу свободная от (2S,3S)-N-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамида или его фармацевтически приемлемой соли, (2R,
