Konstantin Valentinovich Gaidul;Viktor Lvovich Limonov;Aleksandr Valerevich Dushkin
发明人:
Viktor Lvovich Limonov,Konstantin Valentinovich Gaidul,Aleksandr Valerevich Dushkin
申请号：
US13650323
公开号：
US20140105936A1
申请日:
2012.10.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The proposed compositions and methods for preparation thereof relate to pharmacology, medicine, veterinary science and pharmaceutical industry. The compositions can be used for preparing infusion solutions of antimicrobial (antibacterial and antifungal) preparations increasing therapeutic efficiency thereof. The compositions include nanostructured colloidal silica and are efficient when treating overwhelming sepsis of tested animals, provoked by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The pharmaceutical compositions have a proven and significant clinically important potentiating impact on therapeutic efficiency of the infusion solutions, when treating inflammatory diseases, in comparison with traditional solvents. The methods include—obtaining a mixture of colloidal silica with sodium chloride or with dextrose in a certain weight ratio, which mixture includes a mass fraction of fine-dispersed particles of colloidal silica, having dimensions not exceeding 5 micrometers, and —subjecting the mixture to impacting-abrasive actions, until the mass fraction is increased at least twice.
