SHAFFERMAN, AVIGDOR,ZVI, ANAT,ARIEL, NAOMI,FULKERSON, JOHN,SUN, RONGGAI,CHANG, ROSEMARY,SADOFF, JERALD, C.
申请号：
EP08853526
公开号：
EP2235163A4
申请日:
2008.11.26
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
