DERIVES DE N-(PHENYL)-2-(PHENYL)PYRIMIDINE-4-CARBOXAMIDE ET COMPOSES APPARENTES UTILISES EN TANT QU'INHIBITEURS DE HPK1 POUR LE TRAITEMENT DU CANCER

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专利权人:

INCYTE CORPORATION

发明人:

VECHORKIN, OLEG,PAN, JUN,SOKOLSKY, ALEXANDER,STYDUHAR, EVAN,YE, QINDA,YAO, WENQING

申请号：

CA3091517

公开号：

CA3091517A1

申请日:

2019.02.19

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The present invention relates to N-(phenyl)-2-(phenyl)pyrimidine-4- carboxamide derivatives and related compounds of formula I as HPK1 (Hematopoietic progenitor kinase 1) inhibitors for treating cancer, such as e.g. breast cancer, colorectal cancer, lung cancer, ovarian cancer, and pancreatic cancer. Preferred compounds are e.g. N-(5-Fluoro-2-(2-(pyridin-2-yl)pyrrolidin-l-yl)phenyl)-2-(2- fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide and N-(5-Fluoro-2- (hexahydropyrrolo[3,4-b]pyrrol-l(2H)-yl)phenyl)-2-(2-fluoro-6- methoxyphenyl)pyrimidine-4-carboxamide.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/