PROBLEM TO BE SOLVED: To provide a new compound which is a reversible and selective inhibitor of type 2 methionine aminopeptidase and is effective for lung and liver fibrosis, and diseases, in which reactivation of angiogenesis is involved, such as diabetic retinopathy, age-related macular degeneration, psoriasis, cancer, and the like, and to provide a pharmaceutical composition containing the compound.SOLUTION: There are provided the compound represented by formula (I) and the pharmaceutical composition containing the compound. In the formula (I), R1 is a 1-4C alkyl group or the like, R2 is a pyridyloxy group, a pyridylamino group, or the like, and R3 is hydrogen, a halogen, a 1-6C alkyl group, a carboxyl group, or the like.COPYRIGHT: (C)2013,JPO&INPIT【課題】2型メチオニンアミノペプチダーゼの可逆的また選択的阻害剤であり、肺および肝臓の線維症、血管新生の再活性化が関与している病態、例えば糖尿病性網膜症、加齢黄斑変性、乾癬、癌などに有効な新規化合物、及び該化合物を含有する医薬組成物の提供。【解決手段】式(I)で表される化合物、及び該化合物を含有する医薬組成物。(式中、R1は、炭素数1~4のアルキル基など、R2は、ピリジルオキシ基、ピリジルアミノ基など、R3は、水素、ハロゲン、炭素数1~6のアルキル基、カルボキシル基などを表す。)【選択図】なし
