Disclosed is a transdermal therapeutic system for administering at least one active pharmaceutical ingredient which is involatile at room temperature with a daily dose not exceeding 30 mg, comprising a backing layer which is impermeable for the active ingredient and faces away from the skin, an adjoining polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m2, an adhesive skin-contact layer which is adjacent to the polymer layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2, and a protective layer which can be detached from the skin-contact layer and is impermeable for the active ingredient, characterized in that after lamination and diffusion equalization the predominant part of the active ingredient(s) present in the polymer layer remote from the skin on production of the transdermal therapeutic system is or are migrated into the skin-contact layer.
