DANIEL HUNZIKER,PATRIZIO MATTEI,HARALD MAUSER,MARCO PRUNOTTO,CHRISTOPH ULLMER
申请号：
ARP130102060
公开号：
AR091416A1
申请日:
2013.06.12
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Compositions containing these compounds and use of the compounds for the treatment of diseases mediated by inhibition of ATX and LPA.Claim 1: compounds of the formula (1) which is haloalquilo: r u00b9 alkyl, cycloalkyl substituted phenyl, SUBSTITUTED, fenilalquilo, fenoxialquilo replaced, fenilcicloalquilo replaced, fenilalquenilo replaced, fenilalquinilo substituted pyridinyl substituted, its piridinilalquilo Stituido, piridinilalquenilo replaced, piridinilalquinilo replaced, tiofenilo replaced,Tiofenilalquilo replaced, tiofenilalquenilo replaced, tiofenilalquinilo replaced, 2,3 dihydro - - ISO - 1H indole thiocyanatoacetate substituted 1h indole, benzofuran thiocyanatoacetate thiocyanatoacetate replaced or substituted phenyl substituted, such fenilalquilo, replaced, fenoxialquilo replaced, fenilcicloalquilo replaced, FENI Lalquenilo replaced, fenilalquinilo substituted pyridinyl substitutedPiridinilalquilo replaced, piridinilalquenilo replaced, piridinilalquinilo replaced, tiofenilo replaced, tiofenilalquilo replaced, tiofenilalquenilo replaced, tiofenilalquinilo replaced, 2,3 dihydro - - ISO - 1H indole thiocyanatoacetate substituted 1h indole thiocyanatoacetate replaced and substituted benzofuran thiocyanatoacetate Are replaced by r u2078, r u2079 and r u00b9 u2070, but in case it is r u00b9 and alkyl, - C (o) -,Then r u00b3 is chosen among the groups of formula (22) to (39)； R u00b2 is - (cr u2074r u2075 u2099 r u00b3) -, - C (o) - r u00b3, - S (o) r u00b3 u2082 - or - C (o) - nr u2076r u00b3； and is co (or nr u00b9 u2074c (-, -) (O) -, - C (o) -, - S - u2082, (OR) or a formula (2) or (3), but in the case of fenilalquenilo r u00b9 is replaced, piridinilalquenilo. Tiofenilalquenilo formed or replaced,Then it's not OC - and (OR)； W is chosen among the Ring Systems of formula (4) to (21)； but in the case that W is one of the systems of Ring of formula (16) and (17), then r u00b3 is chosen among the groups of formula (22) (39) and in the case that W is the Ring
