A therapy system including a control unit for treatment of an animate body. The system includes a therapy wrap including at least one heat transfer device adapted to exchange heat with the animate body and a control unit. The control unit includes an input device for receiving an input signal, a processor for determining a treatment protocol based on the received input signal, and a controller for administering treatment to the animate body using the therapy wrap based on the determined treatment protocol. Also disclosed are methods of administering a temperature-controlled treatment to an animate body.