An interventional medical device and a manufacturing method thereof. The interventional medical device comprises: a support body (1) a surface of the support body (1) being provided with a medicine releasing structure (3) and medicine in the medicine releasing structure (3) being medicine for suppressing proliferation of adventitial fibroblasts and a medicine for suppressing proliferation of intimal and/or smooth muscle cells. In use after the interventional medical device is implanted in a human body the medicine for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel and the medicine for suppressing proliferation of intimal and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of medicine greatly reduces the occurrence rate of in stent restenosis.
