NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SP
发明人:
Matthew E. Cunningham,Agata Krzyzanowska
申请号：
US16368042
公开号：
US20190282672A1
申请日:
2019.03.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This invention relates to compositions and methods for activating and promoting mineralization in tissue that does not normally mineralize, specifically intervertebral discs. The composition comprises agents that increase the expression of the gene that encodes TNAP and/or the activation, amount or activity of TNAP protein, and agents that decrease the expression of ANK and/or ENPP and/or the activation, amount or activity of these proteins. The composition can be in the form of a cell or cells. The invention also relates to methods of using the composition.
