UNIVERSITE CLAUDE BERNARD LYON I;INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON;UNIVERSITE JEAN MONNET. SAINT ETIENNE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSERM (INSTITUT NATIONAL DE LA SA
The present invention relates to chitosan hydrogel microparticles of a median size d50 comprised between 1 and 500 μm (obtained from a number distribution), the chitosan having a degree of acetylation of less than equal to 20% and its concentration in the hydrogel being comprised between 0.25 and 5% by weight based on a total weight of the hydrogel, for use in neuron regeneration and/or in the repair of the nervous system, advantageously of the central nervous system, and/or in the grafting of neurons and/or in the treatment of neurodegenerative diseases and/or in the treatment of paralyses.It also relates to an implant comprising an aqueous suspension of microparticles mixed with Schwann cells and/or stem cells and/or trophic factors.
