A pressure support system includes a pressure generating system structured to generate a flow of breathing gas, a patient circuit including a patient interface device, the patient circuit being coupled to the pressure generating system and structured to carry the flow of breathing gas, a barometric pressure sensor coupled to the patient circuit within a gas flow path of the patient circuit, wherein the barometric pressure sensor is structured to generate a barometric pressure signal indicative of a barometric pressure within the gas flow path proximate the patient, and a control system. The control system is structured to control an outlet pressure of the pressure generating system based on at least the barometric pressure signal in a manner that compensates for a pressure drop across the patient circuit due to a pneumatic resistance of the patient circuit.
