The present invention relates to flexible liposomal formulation containing atenolol for oral route for improved absorption from the gastrointestinal tract. The flexible liposome comprises Phospholipid, non-ionic surfactant and membrane stabilizer. The vesicles thus obtained are highly flexible. An edge activator is used in such concentration that it gives entrapment efficiency and enhanced permeability. Bioavailability of flexible liposomes was 3.54 times more than marketed product.
