PROBLEM TO BE SOLVED: To provide a bone resorption inhibitor that inhibits bone resorption acting of osteoclasts and food and drink products, medicine, or feed for bone resorption inhibition.SOLUTION: The novel bone resorption inhibitor includes, as an active ingredient, at least any one of &bgrmicroglobulin, histone, the third component of complement, and monocyte chemotactic protein-1. The food and drink product, medicine, or feed for bone resorption inhibition is obtained by the blend of at least any one of &bgrmicroglobulin, histone, the third component of complement, and monocyte chemotactic protein-1.