INOUE, TAN,SAITO, HIROHIDE,KASHIDA, SHUNICHI,HAYASHI, KARIN
申请号：
EP09831915
公开号：
EP2390324A4
申请日:
2009.12.09
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
An object of the present invention is to provide an RNAi control system using an RNA-protein interaction motif. The present invention provides an shRNA comprising: a guide strand having a sequence complementary to a target sequence a passenger strand which forms a duplex with the guide strand and a linker strand which links the guide strand and the passenger strand, wherein the linker strand comprises an RNP-derived protein-binding motif sequence. The present invention also provides an RNAi control system comprising: the shRNA and an RNP-derived protein which specifically binds to a protein-binding motif sequence in the shRNA.
