monoclonal antibody or antigen-binding fragment thereof, pharmaceutical composition, monoclonal antibody or antigen-binding fragment thereof for use, method of treating ischemia-reperfusion injury, method of treating cancer in a human patient, method of evaluating expression CD47 into tumor and / or immune cells using a monoclonal antibody or antigen-binding fragment thereof
JUAN C. ALMAGRO,PAMELA MANNING,ROBERT W. KARR,ROBYN PURO
申请号：
BR112018005322
公开号：
BR112018005322A2
申请日:
2016.09.17
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
anti-cd47 monoclonal antibodies (anti-cd47 mabs) with distinct functional profiles are provided as described herein, methods for generating anti-cd47 mabs and methods of using these anti-cd47 mabs as therapeutic agents for the prevention and treatment of solid and haematological cancers. , ischemia-reperfusion injury, cardiovascular disease, autoimmune disease, inflammatory disease or as a diagnosis to determine the level of cd47 in tissue samples.são proporcionados anticorpos monoclonais anti-cd47 (mabs anti-cd47) com perfis funcionais distintos como descrito aqui, métodos para gerar mabs anti-cd47 e métodos de uso destes mabs anti-cd47 como agentes terapêuticos para a prevenção e tratamento de cânceres sólidos e hematológicos, lesão de isquemia-reperfusão, doenças cardiovasculares, doenças autoimunes, doenças inflamatórias ou como diagnóstico para determinar o nível de cd47 em amostras teciduais.
