GUZZO, PETER,SURMAN, MATTHEW DAVID,HENDERSON, ALAN JOHN,JIANG, MAY XIAOWU,HADDEN, MARK,GRABOWSKI, JAMES,USYATINSKY, ALEXANDER
申请号：
CA2727055
公开号：
CA2727055C
申请日:
2009.01.09
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Substituted pyridoindoles for incorporation in pharmaceutical compositionsemployed in the treatment of variousdiseases correspond to formula (I) wherein R1 is H or optionally substitutedalkyl； R2, R3, R4 are each independently selected from H,-O-alkyl, -S-alkyl, alkyl, halo, -CF3, and -CN； G is -CR12R13-NR5- or R13； R5is H, optionally substituted alkyl, optionallysubstituted heterocycle, -C(=O)-R6,-C(=O)-O-R7, or -C(=O)-NR19R20； R6 and R7are each optionally substituted alkyl or optionallysubstituted heterocycle； R8, R9, R10, R11, R12, R13, R19 and R20 are eachindependently selected from H or optionally substitutedalkyl； R14 and R15 are each independently H or halogen； L is -CH2-O-, -CH2CH2-, -CH=CH- or a bond； and B is aryl or heteroaryl orcycloalkyl； with the proviso that, when L is a direct bond, B cannot beunsubstituted heteroaryl or heteroaryl monosubstituted withfluorine.
