An image sensor system, comprising: an image sensor including an image sensing pixel array; a supporting module; a ground line coupling the image sensor with the supporting module; a power line coupling the image sensor with the supporting module; a data/control line coupling the image sensor with the supporting module; and a clock line coupling the image sensor with the supporting module; wherein the ground line and the power line are based on electrical conduction, and wherein the clock line is based on fiber optics.