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COMPOSES HETEROARYLE BICYCLIQUES FUSIONNES EN 6-6 ET LEUR UTILISATION COMME INHIBITEURS DE LATS
专利权人:
NOVARTIS AG
发明人:
BEHNKE, DIRK,BERENSHTEYN, FRADA,HAO, XUESHI,HOFFMAN, TIMOTHY,JIN, QIHUI,LACOSTE, ARNAUD,LEE, CAMERON,LIU, JUN,LIU, YAHU,MAIBAUM, JUERGEN KLAUS,MO, TINGTING,PAN, JIANFENG,QU, XIN,TCHORZ, JAN,XIE, YUN F
申请号:
CA3056906
公开号:
CA3056906A1
申请日:
2018.04.26
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The present invention is related to 6-6 Fused Bicyclic Heteroaryl Compounds of the Formula A2 or A1 and their Use as LATS Inhibitors, or a salt, stereoisomer or pharmaceutical composition thereof; wherein the variables are as defined herein (A1 & A2). The present invention further relates to a method of LATS inhibition in a cell population using a compound of Formula A1, or a salt, stereoisomer or pharmaceutical composition thereof. The present invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, their use in the treatment and management of diseases or disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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