The present invention relates to a composition comprising a colloidal dispersion and a drug of interest (“AOI”), the colloidal dispersion comprising variable colloidal particles, wherein the AOI is not associated with the variable colloidal particles. The invention also provides kits and transdermal drug release devices comprising the compositions of the invention, and the use of these compositions in medicine, skin care and cosmetics. [Selection figure] None本発明は、コロイド分散系と目的薬剤(「AOI」)とを含み、コロイド分散系は可変コロイド粒子を含み、AOIは可変コロイド粒子と結合していない組成物に関する.本発明は、本発明の組成物を含むキットおよび経皮薬物放出デバイス、並びに薬、スキンケアおよび化粧品におけるこれらの組成物の使用も提供する。【選択図】なし