Steinar Johan Engelsen;Ingvild Johanne Haug;Magnus Hattrem;Tore Seternes;Kurt Ingar Draget
发明人:
Kurt Ingar Draget,Steinar Johan Engelsen,Tore Seternes,Magnus Hattrem,Ingvild Johanne Haug
申请号：
US14111442
公开号：
US20140163108A1
申请日:
2011.10.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides an oral pharmaceutical composition, optionally in dose unit form, comprising a lipophilic drug substance in dispersion in a physiologically tolerable aqueous carrier, preferably an aqueous gel, wherein said drug substance contains a functional electrostatic group having a pKa value of from 2 to 10, characterised in that said aqueous carrier has a pH at least 0.3 below or above said pKa value, said pH being below said pKa where said group is acidic and above said pKa where said group is basic.
