Antibody or fragment thereof which specifically binds a Human variant of csf-1r, Pharmaceutical composition containing same and their use for the manufacture of a Medicament used for treating Cancer and Method for determining whether a subject is a candidate for Cancer Treatment based and
Antibody, or a fragment thereof, that specifically binds the variant of csf-1r (colony stimulating factor receptor (Human): 15 sec id NS), comprising a cdrh1 comprising the sequence sygmh (SEC ID no: 1), a cdrh2 comprising the sequence viwydgsnkyyadsvkg (SEC ID no: 2) a Cdrh3 comprising the sequence gdyevdygmdv (SEC ID no: 3)A cdrl1 comprising the sequence rasqgisnala (SEC ID no: 4), a cdrl2 comprising the sequence dassles (SEC ID no: 5), and a cdrl3 comprising the sequence qqfnsypwt (SEC ID no: 6) or specifically binds to Human csf-1r (SEC ID no: 16), comprising a cdrh1 which comprises the sequence Sygmh (SEC ID no: 1), a cdrh2 comprising the sequence viwydgsnkyyadsvkg (SEC ID no: 2)A cdrh3 comprising the sequence gdyevdygmdv (SEC ID no: 3), a cdrl1 comprising the sequence rasqgisnala (SEC ID no: 4), a cdrl2 comprising the sequence dassles (SEC ID no: 5), and a cdrl3 comprising the sequence qqfnsypwt (SEC ID no: 6). Pharmaceutical composition containing same. Its use for the manufacture of a Medicament useful for the treatment of cancer.Method for determining whether a subject has a cancer is a candidate for a Cancer Treatment regimen based on this Antibody. These Antibodies are multifunctional: inhibit the Signalling of csf-1r, internalized and induce the degradation of csf-1r and stimulate ADCC in including tumor cells, macrophages and monocytes.Винахід стосується антитіла, яке зв'язує варіант людського CSF-1R (SEQ ID NO: 15) з високою спорідненістю.
