Aspergillus sp. KMD 901 strain, diketopiperazines isolated therefrom, and a composition for the prevention of the treatment of cancer comprising the same
PURPOSE: A novel compound isolated from Aspergillus sp. KMD901 is provided to be used as a anticancer agent. CONSTITUTION: An Aspergillus sp. strain(deposit number KCCM 11047P) is derived from marine deposit soil. A composition for preventing or treating cancer contains Aspergillus sp. strain, culture material of the strain, dried material or concentrate of the culture material, organic solvent extract which is obtained from the culture using ethyl acetate, alcohol of C1-C4, methylene chloride, ether, or chloroform, or fraction. A composition for preventing or treating cancer contains acetylaranotin of chemical formula 1, acetylapoaranotin of chemical formula 2, dehydro-deoxyapoaranotin of chemical formula 3 or pharmaceutically acceptable salt thereof as an active ingredient.해양퇴적토로부터 유래한 아스퍼질러스 속 곰팡이 균주 KMD 901 (Aspergillus sp.KMD 901), 이로부터 분리된 신규 화합물 디하이드로-디옥시아포아라노틴(Dehydro-deoxyapoaranotin), 아세틸아라노틴(Acetylaranotin), 및 아세틸아포아라노틴(Acetylapoaranotin), 및 이들의 암세포 성장 억제에 있어서의 용도가 제공된다. 상기 해양퇴적토로부터 분리된 곰팡이 및 이로부터 유래하는 이차 대사산물들은 항암제를 위한 후보물질로 유용하게 사용할 수 있다.
