National University Corporation Tokyo Medical and Dental University
发明人:
申请号：
EP18823662.4
公开号：
EP3647423A1
申请日:
2018.06.29
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Provided is a nucleic acid inhibiting a function of a target miRNA. Provided is a double-stranded nucleic acid complex comprising a first nucleic acid strand of 6 to 30 nucleotide length that hybridizes to a target miRNA to inhibit a function of the target miRNA, and a second nucleic acid strand complementary to the first nucleic acid strand, wherein the first nucleic acid strand is a mixmer comprising a natural nucleoside and a non-natural nucleoside, and the second nucleic acid strand comprises at least one of one or more modified internucleoside linkages and one or more sugar modified nucleosides.
