A catheter for delivering an agent to targeted tissue of a mammalian body includinga first elongate tubular member having a proximal opening and a distal end wall.A second elongate tubular member having a portion extends through first elongatetubular member and has a distal end extending beyond the end wall. The first andsecond tubular members form an annular cavity within the first tubular member.A stiffening member has at least a portion disposed within the annular cavityfor facilitating accurate placement of the distal end relative to the targetedtissue in the mammalian body and is removeable from the annular cavity after suchplacement without removal of the second elongate tubular member from the mammalianbody. A method is provided.