An electrode device is configured to be coupled to a parasympathetic site of a subject. A control unit is configured to drive the electrode device to apply a current in bursts of one or more pulses, during “on” periods that alternate with low stimulation periods, wherein at least one of the low stimulation periods immediately following the at least one of the “on” periods has a low stimulation duration equal to at least 50% of the “on” duration set the current applied on average during the low stimulation periods to be less than 20% of the current applied on average during the “on” periods and ramp a number of pulses per burst during a commencement of the at least one of the “on” periods and/or a conclusion of the at least one of the “on” periods.
