PACKHAEUSER, CLAUDIA BETTINA,STEIGER, NORBERT KARL,LIEPOLD, BERND HARALD,KOSTELAC, DRAZEN,KNOBLOCH, MARTIN GERHARD
申请号：
TW103146100
公开号：
TW201529572A
申请日:
2010.06.07
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The invention relates to a pharmaceutical dosage form which comprises a solid dispersion product comprising N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl) propyl)amino)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide or a salt, hydrate or solvate thereof, at least one pharmaceutically acceptable polymer, and at least one pharmaceutically acceptable solubilizer. The invention is further directed to processes for preparing the pharmaceutical dosage form and to use of the dosage form for treating proliferative disorders.本發明係關於一種醫藥劑型，其包含一種包含N-(4-(4-((2-(4-氯苯基)-5,5-二甲基-1-環己-1-烯-1-基)甲基)哌嗪-1-基)苯甲醯基)-4-(((1R)-3-(嗎啉-4-基)-1-((苯基硫基)甲基)丙基)胺基)-3-((三氟甲基)磺醯基)苯磺醯胺或其鹽、水合物或溶劑化物、至少一種醫藥可接受聚合物及至少一種醫藥可接受增溶劑之固態分散體產品。本發明另關於製備該醫藥劑型之方法，及該劑型於治療增生性疾病之用途。
