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NOVEL FORMS OF CDDO METHYL ESTER
专利权人:
REATA PHARMACEUTICALS; INC.
发明人:
JOHN WALLING,STEPHAN D. PARENT,DAVID T. JONAITIS
申请号:
PT12153605
公开号:
PT2450057T
申请日:
2008.08.14
申请国别(地区):
PT
年份:
2016
代理人:
摘要:
A triterpenoid compound, methyl 2-cyano-3,12-dioxo-Ieana- 1,9(11)-dien-28-oate (CDDO methyl ester), has a crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.
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