Targeting system and device for positioning of a medical sub device with respect to a medical device, wherein a reference body is reproducibly positioned with respect to a targeting device coupling section and reproducibly positioned with respect to a targeting unit, wherein the targeting unit has a targeting direction and is adjustable with respect to the targeting device so that the targeting direction points toward a medical sub device receptacle of a medical device to be coupled to the targeting device coupling section, wherein the imaging system is positionable with respect to the targeting device such that the imaging system is capable of imaging a single two-dimensional view of the reference body and a medical sub device receptacle, wherein the evaluation unit is adapted to generate position data of the single two-dimensional view and to determine from the position data a lateral distance between the targeting direction and a receiving direction of a medical sub device receptacle of a medical device to be coupled.
