USE OF E. COLI SURFACE ANTIGEN 3 SEQUENCES FOR THE EXPORT OF HETEROLOGOUS ANTIGENS

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专利权人:

Jonathan Telfer

发明人:

Jonathan Telfer,Mark Richard Redfern

申请号：

US13125533

公开号：

US20120064114A1

申请日:

2009.10.21

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention provides an export signal system based on E. coli CS3 antigen for directing the secretion of foreign antigens from host cells. In particular, the invention describes genetic constructs encoding fusion proteins that contain a CS3 export signal fused to at least one heterologous amino acid sequence. Attenuated microorganisms expressing the fusion proteins and pharmaceutical compositions comprising such attenuated microorganisms are also disclosed.

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