Ported catheter assemblies (100, 207) are disclosed that include a catheter hub (10) having a distal end, an interior cavity, and a proximal end, a port (15) extending from the catheter hub (10) and communicating with the interior cavity of the catheter hub (10), a catheter (40) extending from the distal end of the catheter hub (10), and a seal formed between the port and the interior cavity of the catheter hub. The port (15) is radially offset from the catheter hub (10), such that a central axis of the port and a central axis of the interior cavity of the catheter hub (10) do not intersect and are offset from each other. An in-line port is also disclosed.
