The present invention relates to a biological tissue diagnosis apparatus, which comprises: at least one lighting control unit for irradiating a contrast agent excitation energy on at least one tissue of interest within a living body in which an imaging contrast agent has been injected at least one inspection unit for imaging an energy radiated from the at least one tissue of interest and a determination unit for determining, on the basis of the image data imaged by the at least one inspection unit, whether a tube or perfusion of the at least one tissue of interest is abnormal.