A blended sweetener mixture that includes multiple high-intensity sweeteners, optionally combined with one or more bulk sweeteners such as sugar. Combining multiple high-intensity sweeteners creates synergistic effects on taste, while limiting the toxicity from any one ingredient. Mixtures of three or more high-intensity sweeteners may limit the sweetness contribution of any single ingredient to no more than 80% of the total sweetness of the mixture, and limit the sweetness contribution of any two ingredients to no more than 90% of the total sweetness of the mixture. Illustrative high-intensity sweeteners used in embodiments may include for example stevia, sucralose, neotame, and acesulfame potassium； illustrative bulk sweeteners may include for example bulk sugar, bulk powdered or agglomerated sugar, and bulk erythritol. Combinations of multiple high-intensity sweeteners and bulk sweeteners may for example provide effective sugar substitutes with equivalent or greater sweetness, lower calories, and lower glycemic loads.
