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PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING ALCOHOLIC LIVER DISEASES, CONTAINING CILOSTAZOL AS ACTIVE INGREDIENT
专利权人:
Jong-Ryul Eun;Youn-Ju Lee;Jong-Yeon Kim
发明人:
Jong-Yeon Kim,Jong-Ryul Eun,Youn-Ju Lee
申请号:
US13880792
公开号:
US20130267558A1
申请日:
2011.10.07
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Provided is a pharmaceutical composition for the treatment and prevention of alcoholic liver diseases, including cilostazol as an active ingredient. Cilostazol inhibits expression levels of TNF-α and FAS (fatty acid synthase) gene in a concentration-dependent manner, and also significantly inhibits the activity of caspase-3. Accordingly, cilostazol shows superior effects for the treatment or prevention of alcoholic liver diseases, in particular, alcoholic hepatitis compared to pentoxifylline which is conventionally used as a therapeutic agent for the treatment for alcoholic hepatitis. Thus, cilostazol is suitable for use as a drug for the treatment or prevention of alcoholic hepatitis.
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中国工程科技知识中心
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