JONES, FRANK R.,BALINT, JOSEPH,LATCHMAN, YVETTE,RICE, ADRIAN,GABITZSCH, ELIZABETH
申请号：
CA3026342
公开号：
CA3026342A1
申请日:
2017.06.02
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Methods and compositions for constructing and producing recombinant adenovirus- based vector vaccines are provided. In particular aspects, there are be provided compositions and methods involving adenovirus vectors comprising genes for target antigens, such as pro state-specific antigen (PSA), pro state- specific membrane antigen (PSMA), MUCl, CEA, and/or Brachyury, and costimulatory molecules for use in treatment methods that generate highly reactive anti-tumor immune responses and that allows for multiple vaccinations in individuals with preexisting immunity to adenovirus.
