INHIBITION DE LIAISON DE LIGAND CCL5 A UN RECEPTEUR CCR5 ET MODIFICATION DE SIGNALISATION D'AXE CCR5/CCL5 DANS UNE INFLAMMATION, UN CANCER, UNE MALADIE AUTO-IMMUNITAIRE OU D'AUTRES ETATS
Methods for the therapeutic use of competitive inhibitors of the CCR5/CCL5 axis that express antagonist activity for RANTES (CCL5) for immunomodulatory treatment of subjects in need thereof. The competitive inhibitors may not have CCL5 agonist activity and can be used to inhibit, interrupt, block, mitigate, slow the progress of, and/or treat inflammation and/or various other CCR5/CCL5 axis signaling dependent down-stream activities associated with transplantation, including graft versus host disease, autoimmune disorders, infectious agents, chronic inflammation, and cancer, etc.
