Provided is a cartridge for treating a dental root including: a cap storing a treatment material therein; a needle arranged at an end of the cap to transfer the treatment material stored in the cap to the dental root; and a handle mounted on the outer circumferential surface of the cap to combine the cap to a device for treating the dental root, wherein the cap has a retaining jaw formed on a portion, to which the handle is fit, along the circumferential surface, and the handle has a rotation support hole for inserting the cap into the handle and a plurality of spilt pieces formed at a smaller-diameter outlet of the rotation support hole to push and pressurize the retaining jaw.