BERDINI, VALERIO,O'BRIEN, MICHAEL ALISTAIR,CARR, MARIA GRAZIA,EARLY, THERESA RACHEL,NAVARRO, EVA FIGUEROA,GILL, ADRIAN LIAM,HOWARD, STEVEN,TREWARTHA, GARY,WOOLFORD, ALISON JO-ANNE,WOODHEAD, ANDREW JAM
申请号：
ES04743172
公开号：
ES2443995T3
申请日:
2004.07.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (VII): or a salt, N-oxide or solvate thereof； where A is - (CH2) m- (B) n-； where m is 0 or 1, n is 1 and B is C>； = O or NRg (C>； = O)； Ra is hydrogen； R1d is a group R1 where R1 is hydrogen, a carbocyclic or heterocyclic group having 3 to 12 ring members, or an optionally substituted C1-8 hydrocarbyl group； where the optional substituents for the C1-8 hydrocarbyl group are selected from hydroxy, oxo, alkoxy, carboxy, halogen, cyano, nitro, amino, mono- or di-hydrocarbylamino C1-4, and carbocyclic and heterocyclic monocyclic or bicyclic groups having 3 to 12 members in the ring； and, where the carbocyclic and heterocyclic groups in each case are unsubstituted or substituted with one or more R10 substituent groups selected from halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, mono- or di-hydrocarbylamino C1-4, carbocyclic groups and heterocyclics having 3 to 12 members in elanillo； a Ra-Rb group where Ra is a bond, O, CO, X1C (X2), C (X2) X1, X1C (X2) X1, S, SO, SO2, NRc, SO2NRc or NRcSO2； and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having 3 to 12 members in elanillo, and a C1-8 hydrocarbyl group optionally substituted with one or more substituents selected from hydroxy, oxo, halogen, cyano, nitro, carboxy, amino, mono- or di-hydrocarbonylamino C1-4, carbocyclic and heterocyclic groups having 3 to 12 ring members and where one or more carbon atoms of the C1-8 hydrocarbyl group may be optionally replaced with O, S, SO, SO2, NRc , X1C (X2), C (X2) X1 or X1C (X2) X1； or two adjacent R10 groups, together with the carbon atoms or heteroatoms to which they are attached can form a 5-membered heteroaryl ring or a 5 or 6-membered non-aromatic carbocyclic or heterocyclic ring, where the mentioned heteroaryl and heterocyclic groups contain up to 3 elanillo members that are heteroatoms selected from N, O and S； Rc is selected from hydrogen and C1-4 hydrocarbyl； and X1 is O, S or NRc and X2 is>； = O,>； = S o
