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Aminotriazoles as PI3K inhibitors
专利权人:
Cellzome Limited
发明人:
RAMSDEN, Nigel,BELL, Kathryn,CANSFIELD, Andrew,TAYLOR, Jess,SUNOSE, Mihiro,MIDDLEMISS, David,NEUBAUER, Gitte
申请号:
ES08854698
公开号:
ES2558840T3
申请日:
2008.11.21
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, wherein X is NH2; R1, R2, R3 are independently selected from the group consisting of H; halogen; CN; C (O) OR4; OR4; C (O) R4; C (O) N (R4R4a); S (O) 2N (R4R4a); S (O) N (RaR4a); S (O) 2R4; S (O) R4; N (R4) S (O) 2N (R4aR4b); N (R4) S (O) N (R4aR4b); SR4; N (R4R4a); OC (O) R4; N (R4) C (O) R4a; N (R4) S (O) 2R4a; N (R4) S (O) R4a; N (R4) C (O) N (R4aR4b); N (R4) C (O) OR4a; OC (O) N (R4R4a) and C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more halogens, which are the same or different; R4, R4a, R4b are independently selected from the group consisting of H and C1-6 alkyl, in which C1-6 alkyl is optionally substituted with one or more halogens, which are the same or different; T1 is 4-7 membered heterocyclyl; 9-11 member heterobicyclyl; phenyl; naphthyl; indenyl or indanyl; wherein T1 is optionally substituted with one or more R5 and / or one or more R6; R5 is halogen; CN; C (O) OR7; OR7; oxo (>; = O), in which the ring is at least partially saturated; C (O) R7; C (O) N (R7R7a); S (O) 2N (R7R7a); S (O) N (R7R7a); S (O) 2R7; S (O) R7; N (R7) S (O) 2N (R7aR7b); N (R7) S (O) N (R7aR7b); SR7; N (R7R7a); OC (O) R7; N (R7) C (O) R7; N (R7) S (O) 2R7a; N (R7) S (O) R7a; N (R7) C (O) N (R7aR7b); N (R7) C (O) OR7a; OC (O) N (R7R7a); or C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more R8; R6 is T2; C (O) OR9; OR9; C (O) R9; C (O) N (R9R9a); S (O) 2N (R9R9a); S (O) N (R9R9a); S (O) 2R9; S (O) R9; N (R9) S (O) 2N (R9aR9b); N (R9) S (O) N (R9aR9b); SR9; N (R9R9a); OC (O) R9; N (R9) C (O) R9a; N (R9) S (O) 2R9a; N (R9) S (O) R9a; N (R9) C (O) N (R9aR9b); N (R9) C (O) OR9a; OC (O) N (R9R9a) or C1-6 alkyl substituted with one or more T2 and optionally substituted with one or more R8; R9, R9a, R9b are independently selected from the group consisting of R9c and R9d, with the proviso that at least one of R9, R9a, R9b is R9c; R9c is T2 or C1-6 alkyl, w
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