The present invention relates to a method for preventing stem cell disruption and aggregation. The present invention also relates to a stem cell composition for intravascular administration, in which stem cells are suspended in a solution containing aspirin. The present invention also relates to a composition for preventing stem cell disruption or aggregation, in which stem cells are suspending in a solution containing aspirin. According to the present invention, cell disruption and aggregation can be prevented during transport or storage, thus enabling the administered stem cells to stably reach target tissue and exhibit the activity thereof in a more efficient manner, thereby remarkably increasing the effects of cell therapy using stem cells.