KIM, No Soo,PARK, Jong-Shik,YI, Jin-Mu,LEE, You Jin,CHO, Eun-Sang,KIM, Jinhee,LIM, Chae Jun,BANG, Ok-Sun,KIM, Youngah
申请号：
EP15891955
公开号：
EP3295946A4
申请日:
2015.09.30
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to a composition for preventing, alleviating, or treating peripheral neuropathy, in particular, peripheral neuropathy induced by an anti-cancer agent (i.e., chemotherapy-induced peripheral neuropathy), comprising a Lithospermi Radix extract as an effective component. Specifically, the Lithospermi Radix extract can relieve the suppressed growth of neurites caused by an anti-cancer agent while neither inducing any cytotoxicity in normal cells nor changing the unique cytotoxic potential of an anti-cancer agent in human cancer cells. In addition the Lithospermi Radix extract can efficiently lower the enhanced sensitivity to painful stimuli in peripheral neuropathic animals induced by an anti-cancer agent. Thus, the Lithospermi Radix extract can be advantageously used as an effective component of a composition for prevention, alleviation, or treatment of chemotherapy-induced peripheral neuropathy.
