The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an Improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mamma! in need thereof.La solicitud describe compuestos derivados de benzimidazol útiles para combatir la infestación por helmintos en mamíferos. Además, describe composiciones para tratar la infestación por helmintos que comprenden dichos compuestos.