PODSTAWIONE 2-TIOKSOIMIDAZOLIDYN-4-ONY I ICH ANALOGI SPIRO, CZYNNY SKŁADNIK PRZECIWNOWOTWOROWY, KOMPOZYCJA FARMACEUTYCZNA, PREPARAT LECZNICZY, SPOSÓB LECZENIA RAKA GRUCZOŁU KROKOWEGO

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专利权人:

R-PHARM OVERSEAS INC.

发明人:

IVACHTCHENKO, ALEXANDRE VASILIEVICH

申请号：

PL15818878

公开号：

PL3168214T3

申请日:

2015.06.26

申请国别(地区):

PL

年份:

2019

代理人:

摘要：

The invention relates to novel ( R )-stereoisomers of substituted 2-thioxo-imidazolidin-4-ones of formula 1 , or spiro analogues thereof, which exhibit androgen receptor antagonist properties, variants of a method for producing the same, and intermediate compounds for producing compounds of formula 1 . Compounds of formula 1 can be used to produce a medicinal agent suitable for treating cancers, such as prostate cancer and breast cancer. The invention also relates to a pharmaceutical composition in the form of tablets, capsules, injections. In formula 1 wherein R1 is OH, NH 2 , or an OR4 group； R2 and R3 are methyl, or R2 and R3 are a CH 2 -CH 2 group； R4 is C 1 -C 4 alkyl or cyclopropyl.

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