Provided herein are compositions, methods of treatment using such compositions, and methods of making such compositions wherein the compositions comprise a large molecule. The compositions, and devices and kits comprising such compositions provide new and useful improvements as alternatives for addressing diseases, disorders and symptoms thereof in a subject.本文提供組成物、使用該組成物之治療方法、以及製造該組成物之方法,其中該組成物包含大分子。組成物及包含該組成物之裝置和套組提供新穎且有用之改善作為解決個體之疾病、病症及其症狀之替代品。本案圖式為實驗數據和一般皮膚結構的示意圖,故本案無代表圖。