JOHN H. MUSSER,GUY J. LAIDIG,RONALD T. BORCHARDT,CRAIG M. CREWS,MARK S. SMYTH,KEVIN D. SHENK,BARRY A. BUNIN,PEGGY A. RADEL
申请号：
PT08164241
公开号：
PT2030981E
申请日:
2005.05.09
申请国别(地区):
PT
年份:
2014
代理人:
摘要：
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-termmal nucleophile (Nin) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by she compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.
