The present invention relates compounds of Formula (A) as NK-1 receptor antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to NK-1 receptor in humans. More specifically, the compounds and / or pharmaceutical compositions of the present invention are believed to potentially offer therapeutic benefits to patients who suffer, among others, chemotherapy-induced nausea and vomit (CINV) and / or post-operative nausea and vomit (PONV).本發明關於作為NK-1受體拮抗劑之式(A)化合物、以及彼等的製備和用途、及進一步關於包含此等化合物之醫藥組成物和彼等用作功能失調的麩胺酸傳遞的調節劑之用途。本發明亦關於該等化合物或醫藥組成物在治療或預防一些與人類NK-1受體有關的障礙和疾病之用途。更具體地說，本發明之化合物及/或醫藥組成物被認為可能對尤其患有化療引起的噁心和嘔吐(CINV)及/或手術後的噁心和嘔吐(PONV)之患者提供治療益處。
